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Xanax was manufactured for the management of anxiety disorders or for short-range relief of the symptoms of anxiety and panic disorders with or without agoraphobia.
Tension or anxiety related with the tension of everyday life normally does not require treatment with an anxiolytic. Ansiety associated with depression is also receptive to Xanax.
Reports of overdosage with alprazolam immediate release tablets are limited.
Evident signs of alprazolam overdosage include:
- Somnolence - Confusion - impaired coordination - diminished reflexes and coma
Death has been reported in connection with overdoses of alprazolam by itself, as it has with other benzodiazepines. Fatalities have also been reported in patients who have overdosed with a combination of a single benzodiazepine including alprazolam and alcohol. Levels of alcohol seen in some of these patients have been lower than those usually linked with alcohol-induced casualty
No clinical laboratory abnormalities or delayed reactions (organ toxicity) have been reported.
Respiration, pulse rate and blood pressure should be monitored which is similar to that of other drug overdose. General supportive steps must be utilized together with direct gastric lavage. Administration of IV fluids and an adequate airway maintained should be done. Hypotension may be fought by the use of vasopressors, Levophed (levanterenol) or Aramine (metaraminol). Similar to the management of intentional overdosing with any drug, it should be borne in mind that multiple agents may have been ingested.
Xanax is not indicated to patients with known sensitivity to Xanax or other benzodiapines. Xanax may be given to patients with open-angle glaucoma who are receiving appropriate therapy, but is contraindicated in acute anrrow-angle glaucoma.
Xanax XR is contraindicated with ketoconazole and itraconazole, since these medications significantly impair the oxidative metabolism mediated by cytochrome P-450 (CYP3A).
Xanax is of no value in the treatment of psychotic patients and should not be used in lieu of suitable treatment for psychosis.